ACE2 Rabbit pAb
Ucallm_WP5937-50
Price range: $268.00 through $328.00
Product details
Background:
angiotensin I converting enzyme 2(ACE2) Homo sapiens The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63.
Specifications
| Size | 50μL/100μL |
| Target | ACE2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | |
| MW(Observed) | 120-135kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ACE2 AA range: 425-475 |
| Specificity | This antibody detects endogenous levels of ACE2 at Human, Mouse,Rat |
| Gene Name | ACE2 UNQ868/PRO1885 |
| Protein Name | ACE2 |
| Other Name | Angiotensin-converting enzyme 2; / ACE-related carboxypeptidase; / Angiotensin-converting enzyme homolog; / ACEH; / Metalloprotease MPROT15; / [Cleaved into: Processed angiotensin-converting enzyme 2] |
| Species | Human |
| Gene ID | 59272 |
| Uniprot | Q9BYF1, |
| Species.1 | Mouse |
| Gene ID.1 | 70008 |
| Uniprot.1 | Q8R0I0, |
| Species.2 | Rat |
| Gene ID.2 | 302668 |
| Uniprot.2 | Q5EGZ1 |
| Cellular Localization | [Processed angiotensin-converting enzyme 2]: Secreted .; Cell membrane; Single-pass type I membrane protein . Cytoplasm . Cell projection, cilium . Apical cell membrane . Detected in both cell membrane and cytoplasm in neurons. .; [Isoform 2]: Apical cell membrane . |
| Tissue Expression | Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells (at protein level) (PubMed:15141377). Expressed in enterocytes of the small intestine, Leydig cells and Sertoli cells (at protein level) (PubMed:15141377). Expressed in the renal proximal tubule and the small intestine (at protein level) (PubMed:18424768). Expressed in heart, kidney, testis, and gastrointestinal system (at protein level) (PubMed:10969042, PubMed:10924499, PubMed:15231706, PubMed:12459472, PubMed:15671045, PubMed:32715618, PubMed:32170560). In lung, expressed at low levels in some alveolar type 2 cells, the expression seems to be individual-specific (at protein level) (PubMed:32425701, PubMed:15141377, PubMed:32715618, PubMed:32170560, PubMed:33432184). Expressed in nasal epithelial cells (at protein level) (PubMed:33432184, PubMed:32333915). Coexpressed with TMPRSS2 within some lung alveolar type 2 cells, ileal absorptive enterocytes, intestinal epithelial cells, cornea, gallbladder and nasal goblet secretory cells (PubMed:32413319, PubMed:32327758, PubMed:32358202). Coexpressed with TMPRSS4 within mature enterocytes (PubMed:32404436).; [Isoform 2]: Expressed in nasal and bronchial epithelial cells (at protein level). |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Renin-angiotensin system |
| Research Areas | >>Renin-angiotensin system; / >>Protein digestion and absorption; / >>Coronavirus disease - COVID-19 |
| Function |
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