Price range: $268.00 through $328.00
Background:
This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012],
| Target | AChRα9 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human CHRNA9. AA range:50-100 |
| Sequence | |
| Specificity | AChRα9 Polyclonal Antibody detects endogenous levels of cholinergic receptor, nicotinic, alpha 9 |
| Gene Name | CHRNA9 |
| Protein Name | cholinergic receptor, nicotinic, alpha 9 |
| Other Name | Neuronal acetylcholine receptor subunit alpha-9; / Nicotinic acetylcholine receptor subunit alpha-9; / NACHR alpha-9 |
| Species | Human |
| Gene ID-1 | 55584 |
| Uniprot | Q9UGM1, |
| Species.1 | |
| Gene ID-2 | |
| Uniprot.1 | |
| Species.2 | Rat |
| Gene ID-3 | |
| Uniprot.2 | P43144 |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | This gene is a member of the ligand-gated ionic channel family and nicotinic acetylcholine receptor gene superfamily. It encodes a plasma membrane protein that forms homo- or hetero-oligomeric divalent cation channels. This protein is involved in cochlea hair cell development and is also expressed in the outer hair cells (OHCs) of the adult cochlea. [provided by RefSeq, Feb 2012], |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein . Cell membrane; Multi-pass membrane protein . |
| Tissue Expression | Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells. |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Chemical carcinogenesis - receptor activation |
| Function | Function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. May also regulate keratinocyte adhesion.,miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Can form homo- or hetero-oligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.,tissue specificity:Expressed in cochlea, keratinocytes, pituitary gland, B-cells and T-cells., |
| RRID |
