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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/ACO2 Polyclonal Antibody
SKU: WP16006 Categories: ,

ACO2 Polyclonal Antibody

Ucallm_WP16006-50

Price range: $268.00 through $328.00

SKU: WP16006-100
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Product details

Background:

The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],

Specifications

TargetACO2
ReactivityHuman, Mouse, Rat, Canine
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)90kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:5000.Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ACO2. at AA range: 421-470
Sequence
SpecificityACO2 Polyclonal Antibody detects endogenous levels of ACO2
Gene NameACO2
Protein NameACO2
Other NameAconitate hydratase, mitochondrial; / Aconitase; / Citrate hydro-lyase
SpeciesHuman
Gene ID-150
UniprotQ99798,
Species.1Mouse
Gene ID-211429
Uniprot.1Q99KI0
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThe protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008],
Cellular LocalizationMitochondrion .
Tissue ExpressionBrain,Cajal-Retzius cell,Fetal brain cortex,Skeletal muscle,Uterus,
Signaling_pathway
Research Areas>>Citrate cycle (TCA cycle); / >>Glyoxylate and dicarboxylate metabolism; / >>Metabolic pathways; / >>Carbon metabolism; / >>2-Oxocarboxylic acid metabolism; / >>Biosynthesis of amino acids
FunctionCatalytic activity:Citrate = isocitrate.,cofactor:Binds 1 4Fe-4S cluster per subunit. Binding of a 3Fe-4S cluster leads to an inactive enzyme.,online information:Aconitase entry,pathway:Carbohydrate metabolism; tricarboxylic acid cycle.,similarity:Belongs to the aconitase/IPM isomerase family.,subunit:Monomer.,
RRID
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