Name: ACSL6 Polyclonal Antibody
SKU: WP10927
Price: 268 USD
Availability: InStock

Product details

Background:

The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011],

Specifications

Target	ACSL6
Reactivity	Human, Mouse, Rat
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	78kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Modification
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ACSL6. AA range:499-548
Sequence
Specificity	ACSL6 Polyclonal Antibody detects endogenous levels of ACSL6 protein.
Gene Name	ACSL6
Protein Name	Long-chain-fatty-acid--CoA ligase 6
Other Name	ACSL6; / ACS2; / FACL6; / KIAA0837; / LACS5; / Long-chain-fatty-acid--CoA ligase 6; / Long-chain acyl-CoA synthetase 6; / LACS 6
Species	Human
Gene ID-1	23305
Uniprot	Q9UKU0,
Species.1	Mouse
Gene ID-2	216739
Uniprot.1	Q91WC3,
Species.2	Rat
Gene ID-3	117243
Uniprot.2	P33124
Organism-4
Gene ID-4
SwissProt-4
Background	The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011],
Cellular Localization	Mitochondrion outer membrane; Single-pass type III membrane protein . Peroxisome membrane; Single-pass type III membrane protein . Microsome membrane; Single-pass type III membrane protein . Endoplasmic reticulum membrane; Single-pass type III membrane protein .
Tissue Expression	Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Peroxisome;Cellular Processes >> Cell growth and death >> Ferroptosis;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas	>>Fatty acid biosynthesis; / >>Fatty acid degradation; / >>Metabolic pathways; / >>Fatty acid metabolism; / >>PPAR signaling pathway; / >>Peroxisome; / >>Ferroptosis; / >>Thermogenesis; / >>Adipocytokine signaling pathway
Function	Catalytic activity:ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.,cofactor:Magnesium.,developmental stage:Expression is low at earlier stages of erythroid development but is very high in reticulocytes.,Disease:A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5; 12)(q31; p13) with ETV6.,Disease:A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5; 12)(q31; p13) with ETV6.,Disease:A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5; 12)(q31; p13) with ETV6.,Function:Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,tissue specificity:Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, haemopoietic stem cells from cord blood, bone marrow, and brain.,
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ACSL6 Polyclonal Antibody

Product details

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ACSL6 Polyclonal Antibody

Product details

Specifications

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