SKU: WP10929 Categories: ,

ACSVL4 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP10929-100
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Product details

Background:

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010],

Specifications

TargetACSVL4
ReactivityHuman, Mouse
ApplicationsIF, ELISA
MW(Calculated)72kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioIF 1:200-1:1000; ELISA 1:20000; Not yet tested in other applications;
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human SLC27A4. AA range:61-110
Sequence
SpecificityACSVL4 Polyclonal Antibody detects endogenous levels of ACSVL4 protein.
Gene NameSLC27A4
Protein NameLong-chain fatty acid transport protein 4
Other NameSLC27A4; / ACSVL4; / FATP4; / Long-chain fatty acid transport protein 4; / FATP-4; / Fatty acid transport protein 4; / Solute carrier family 27 member 4
SpeciesHuman
Gene ID-110999
UniprotQ6P1M0,
Species.1Mouse
Gene ID-2
Uniprot.1Q91VE0
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
BackgroundThis gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010],
Cellular LocalizationEndoplasmic reticulum membrane; Multi-pass membrane protein .
Tissue ExpressionExpressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue (PubMed:24269233, PubMed:9878842). Expressed in brain gray matter (PubMed:21395585).
Signaling_pathwayOrganismal Systems >> Endocrine system >> PPAR signaling pathway
Research Areas>>PPAR signaling pathway; / >>Insulin resistance; / >>Fat digestion and absorption
FunctionFunction:Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Appears to be the principal fatty acid transporter in small intestinal enterocytes. Plays a role in the formation of the epidermal barrier. Required for fat absorption in early embryogenesis. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids.,miscellaneous:SLC27A4/FATP4-mediated fatty acid uptake is associated to paramaters related to insulin resistance, which is associated with disturbed fatty acid metabolism and homeostasis, such as obesity. SLC27A4/FATP4 expression is positively correlated with aquired obesity.,similarity:Belongs to the ATP-dependent AMP-binding enzyme family.,tissue specificity:Expressed at highest levels in brain, testis, colon and kidney. Expressed at medium levels in heart and liver, small intestine and stomach. Expressed at low levels in peripheral leukocytes, bone marrow, skeletal muscle and aorta. Expressed in adipose tissue.,
RRID
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