ACTA2 Monoclonal Antibody
Ucallm_WM0012-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2008],
Specifications
| Size | 50μL/100μL |
| Target | α smooth muscle actin |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB, IHC, IF, FC, ELISA |
| MW(Calculated) | 42kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; IF 1:200-1:1000; Flow Cyt 1:200-1:400; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9G6 |
| Immunogen | Synthesized peptide of human ACTA2. |
| Specificity | ACTA2 Monoclonal Antibody detects endogenous levels of ACTA2 protein. |
| Gene Name | ACTA2 |
| Protein Name | Actin, aortic smooth muscle |
| Other Name | ACTA2; / ACTSA; / ACTVS; / GIG46; / Actin; / aortic smooth muscle; / Alpha-actin-2; / Cell growth-inhibiting gene 46 protein |
| Species | Human |
| Gene ID | 59 |
| Uniprot | P62736, |
| Species.1 | Mouse |
| Gene ID.1 | 11475 |
| Uniprot.1 | P62737, |
| Species.2 | Rat |
| Gene ID.2 | 81633 |
| Uniprot.2 | P62738 |
| Cellular Localization | Cytoplasm, cytoskeleton. |
| Tissue Expression | Pituitary,Uterus, |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Circulatory system >> Vascular smooth muscle contraction;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway |
| Research Areas | >>Vascular smooth muscle contraction; / >>Apelin signaling pathway; / >>Relaxin signaling pathway |
| Function | Disease:Defects in ACTA2 are the cause of aortic aneurysm familial thoracic type 6 (AAT6) [MIM:611788]. AATs are characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. They are primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.,Function:Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.,miscellaneous:In vertebrates 3 main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins coexist in most cell types as components of the cytoskeleton and as mediators of internal cell motility.,similarity:Belongs to the actin family.,subunit:Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others., |
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