SKU: WP8858 Categories: ,

ACTR3B rabbit pAb

Price range: $268.00 through $328.00

SKU: WP8858-100
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Product details

Background:

Specifications

TargetACTR3B
ReactivityHuman, Mouse
ApplicationsWB
MW(Calculated)46kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Modification
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ACTR3B
Sequence
SpecificityThis antibody detects endogenous levels of ACTR3B at Human, Mouse
Gene NameACTR3B ARP11 ARP4
Protein NameActin-related protein 3B (ARP3-beta) (Actin-like protein 3B) (Actin-related protein ARP4)
Other Name
SpeciesHuman
Gene ID-157180
UniprotQ9P1U1,
Species.1Mouse
Gene ID-2242894
Uniprot.1Q641P0
Species.2
Gene ID-3
Uniprot.2
Organism-4
Gene ID-4
SwissProt-4
Background
Cellular LocalizationCytoplasm, cytoskeleton . Cell projection .
Tissue ExpressionDetected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential.
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis
Research Areas
FunctionPlays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors.
RRID
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