Price range: $268.00 through $328.00
Background:
myeloid/lymphoid or mixed-lineage leukemia; translocated to, 10(MLLT10) Homo sapiens This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010],
| Size | 50μL/100μL |
| Target | AF-10 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 109kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human AF10. AA range:211-260 |
| Specificity | AF-10 Polyclonal Antibody detects endogenous levels of AF-10 protein. |
| Gene Name | MLLT10 |
| Protein Name | Protein AF-10 |
| Other Name | MLLT10; / AF10; / Protein AF-10; / ALL1-fused gene from chromosome 10 protein |
| Species | Human |
| Gene ID | 8028 |
| Uniprot | P55197, |
| Species.1 | Mouse |
| Gene ID.1 | 17354 |
| Uniprot.1 | O54826 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus . |
| Tissue Expression | Expressed abundantly in testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Disease:A chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10; 11)(p12; q23) with MLL/HRX. The result is a rogue activator protein.,Disease:A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10; 11)(p13; q14) with PICALM.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 2 PHD-type zinc fingers.,tissue specificity:Expressed abundantly in testis., |
