U-Blot® AIM2 Rabbit mAb
Ucallm_WR4887-50
Price range: $268.00 through $328.00
Product details
Background:AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AIM2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 39kD |
| MW(Observed) | 43kD |
| Host Species | Rabbit |
| Isotype | IgG,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:200-1:1000; WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | RM1057R |
| Immunogen | The specific immunogen used to produce this antibody is proprietary information. |
| Specificity | Endogenous |
| Gene Name | AIM2 |
| Protein Name | Interferon-inducible protein AIM2 |
| Other Name | AIM2; / Interferon-inducible protein AIM2; / Absent in melanoma 2 |
| Species | Human |
| Gene ID | 9447 |
| Uniprot | O14862, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q91VJ1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. Cytoplasm. Activated inflammasomes can aggregate in the cytosol as speck-like particles. |
| Tissue Expression | Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. |
| Signaling_pathway | Organismal Systems >> Immune system >> NOD-like receptor signaling pathway;Organismal Systems >> Immune system >> Cytosolic DNA-sensing pathway |
| Research Areas | >>NOD-like receptor signaling pathway; / >>Cytosolic DNA-sensing pathway |
| Function | Disease:Defects in AIM2 may be a cause of microsatellite unstable colon cancers.,Function:Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.,induction:By interferon gamma.,similarity:Belongs to the HIN-200 family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 HIN-200 domain.,subunit:Homodimer.,tissue specificity:Expressed in spleen, small intestine, peripheral blood leukocytes, and testis., |
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