AK1 Polyclonal Antibody
Ucallm_WP10988-50
Price range: $268.00 through $328.00
Product details
Background:
adenylate kinase 1(AK1) Homo sapiens This gene encodes an adenylate kinase enzyme involved in energy metabolism and homeostasis of cellular adenine nucleotide ratios in different intracellular compartments. This gene is highly expressed in skeletal muscle, brain and erythrocytes. Certain mutations in this gene resulting in a functionally inadequate enzyme are associated with a rare genetic disorder causing nonspherocytic hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015],
Specifications
| Size | 50μL/100μL |
| Target | AK1 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human KAD1 . AA range:101-150 |
| Specificity | AK1 Polyclonal Antibody detects endogenous levels of AK1 protein. |
| Gene Name | AK1 |
| Protein Name | Adenylate kinase isoenzyme 1 |
| Other Name | AK1; / Adenylate kinase isoenzyme 1; / AK 1; / ATP-AMP transphosphorylase 1; / Myokinase |
| Species | Human |
| Gene ID | 203 |
| Uniprot | P00568, |
| Species.1 | Mouse |
| Gene ID.1 | 11636 |
| Uniprot.1 | Q9R0Y5, |
| Species.2 | Rat |
| Gene ID.2 | 24183 |
| Uniprot.2 | P39069 |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Chondrosarcoma Lung Metastasis,Colon,Fetal brain cortex,Retina,Skeletal muscle,Synovial mem |
| Signaling_pathway | |
| Research Areas | >>Purine metabolism; / >>Thiamine metabolism; / >>Metabolic pathways; / >>Nucleotide metabolism; / >>Biosynthesis of cofactors |
| Function | Catalytic activity:ATP + AMP = 2 ADP.,Disease:Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency [MIM:612631].,Function:Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.,online information:Adenylate kinase entry,polymorphism:This enzyme represents the most common of at least five alleles.,similarity:Belongs to the adenylate kinase family.,subunit:Monomer., |
Please login to post questions
Related products
