Price range: $268.00 through $328.00
Background:
This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | ALDH1B1 |
| Reactivity | Human, Monkey |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 57kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:20000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ALDH1B1. AA range:311-360 |
| Specificity | ALDH1B1 Polyclonal Antibody detects endogenous levels of ALDH1B1 protein. |
| Gene Name | ALDH1B1 |
| Protein Name | Aldehyde dehydrogenase X mitochondrial |
| Other Name | ALDH1B1; / ALDH5; / ALDHX; / Aldehyde dehydrogenase X; / mitochondrial; / Aldehyde dehydrogenase 5; / Aldehyde dehydrogenase family 1 member B1 |
| Species | Human |
| Gene ID | 219 |
| Uniprot | P30837, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9CZS1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion matrix. |
| Tissue Expression | Liver, testis and to a lesser extent in brain. |
| Signaling_pathway | |
| Research Areas | >>Glycolysis / Gluconeogenesis; / >>Ascorbate and aldarate metabolism; / >>Fatty acid degradation; / >>Valine, leucine and isoleucine degradation; / >>Lysine degradation; / >>Arginine and proline metabolism; / >>Histidine metabolism; / >>Tryptophan metabolism; / >>beta-Alanine metabolism; / >>Glycerolipid metabolism; / >>Pyruvate metabolism; / >>Pantothenate and CoA biosynthesis; / >>Metabolic pathways; / >>Biosynthesis of cofactors; / >>Alcoholic liver disease |
| Function | Catalytic activity:An aldehyde + NAD(+) + H(2)O = an acid + NADH.,Function:ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.,pathway:Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.,similarity:Belongs to the aldehyde dehydrogenase family.,subunit:Homotetramer.,tissue specificity:Liver, testis and to a lesser extent in brain., |
