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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/AMACR [ABT-AMACR] mouse mAb
SKU: WM1507 Categories: ,

AMACR [ABT-AMACR] mouse mAb

Ucallm_WM1507-50

Price range: $268.00 through $328.00

SKU: WM1507-50
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Product details

Background:
AMACR is an α Formyl COA racemase localized in peroxisomes and mitochondria . It is an enzyme involved in biosynthesis of bile acid and β-oxidation of branched-chain fatty acids. It is expressed in the epithelium and salivary gland of proximal convoluted tubules of pancreas, liver and kidney, and moderately in paraurethral glands. The expression in prostate cancer is higher than that in benign prostate tissue. In the study of prostate cancer, it is often used in combination with PSA, p63, 34 β E12 and other antibodies.

Specifications

Size50μL/100μL
TargetAMACR
ReactivityHuman
ApplicationsIHC, WB, IF, ELISA
MW(Calculated)42kD
MW(Observed)42kD
Host SpeciesMouse
IsotypeIgG1,Kappa
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-500; WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationPBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
PurificationRecombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone NumberRMM-AMACR
ImmunogenSynthesized peptide derived from human AMACR AA range: 300-382
SpecificityThe antibody can specifically recognize human AMACR protein. In western blotting of Hela and LnCap cell lysates, the antibody can label a 42 kDa band corresponding to AMACR.
Gene NameAMACR
Protein NameAMACR
Other Name2 arylpropionyl CoA epimerase; / 2 methylacyl CoA racemase; / 2-methylacyl-CoA racemase; / Alpha methylacyl CoA racemase; / Alpha methylacyl Coenzyme A racemase; / Alpha methylacyl-CoA racemase deficiency, included; / Alpha-methylacyl-CoA racemase; / Amacr; / AMACR deficiency, included; / AMACR_HUMAN; / CBAS4; / Da1-8; / Macr1; / Methylacyl CoA racemase alpha; / RACE; / RM
SpeciesHuman
Gene ID23600
UniprotQ9UHK6
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasmic
Tissue ExpressionAorta,Brain,Cerebellum,Kidney,Liver,PCR rescued clones,Prostate cancer,Sali
Signaling_pathwayCellular Processes >> Transport and catabolism >> Peroxisome
Research Areas>>Primary bile acid biosynthesis; / >>Metabolic pathways; / >>Peroxisome
FunctionCatalytic activity:(2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA.,Disease:Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency (AMACRD) [MIM:604489]. AMACRD results in elevated plasma concentrations of pristanic acid C27-bile-acid intermediates. It can be associated with polyneuropathy, retinitis pigmentosa, epilepsy.,Disease:Defects in AMACR are the cause of congenital bile acid synthesis defect type 4 (CBAS4) [MIM:214950]; also known as cholestasis, intrahepatic, with defective conversion of trihydroxycoprostanic acid to cholic acid or trihydroxycoprostanic acid in bile. Clinical features include neonatal jaundice, intrahepatic cholestasis, bile duct deficiency and absence of cholic acid from bile.,Function:Racemization of 2-methyl-branched fatty acid CoA esters. Responsible for the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers.,pathway:Lipid metabolism; bile acid biosynthesis.,pathway:Lipid metabolism; fatty acid metabolism.,similarity:Belongs to the caiB/baiF CoA-transferase family.,similarity:Contains 1 C1q domain.,similarity:Contains 1 collagen-like domain.,
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