AMPKβ2 Mouse mAb [Mix-mA]
Ucallm_WM1101-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | AMPKβ2 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, WB |
| MW(Calculated) | |
| MW(Observed) | 30kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | 16B4 |
| Immunogen | Synthesized peptide derived from human AMPKβ2 |
| Specificity | This antibody detects endogenous levels of AMPKβ2 at Human, Mouse,Rat |
| Gene Name | PRKAB2 |
| Protein Name | 5'-AMP-activated protein kinase subunit beta-2 |
| Other Name | PRKAB2; / 5'-AMP-activated protein kinase subunit beta-2; / AMPK subunit beta-2 |
| Species | Human |
| Gene ID | 5565 |
| Uniprot | O43741, |
| Species.1 | Mouse |
| Gene ID.1 | 108097 |
| Uniprot.1 | Q6PAM0, |
| Species.2 | Rat |
| Gene ID.2 | 64562 |
| Uniprot.2 | Q9QZH4 |
| Cellular Localization | nucleoplasm,cytosol,nucleotide-activated protein kinase complex, |
| Tissue Expression | Liver,Pancreas, |
| Signaling_pathway | Cellular Processes >> Cellular community - eukaryotes >> Tight junction;Organismal Systems >> Endocrine system >> Insulin signaling pathway;Organismal Systems >> Endocrine system >> Glucagon signaling pathway;Organismal Systems >> Endocrine system >> Adipocytokine signaling pathway;Organismal Systems >> Endocrine system >> Oxytocin signaling pathway;Organismal Systems >> Aging >> Longevity regulating pathway;Organismal Systems >> Aging >> Longevity regulating pathway - multiple species;Organismal Systems >> Environmental adaptation >> Circadian rhythm;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway;Environmental Information Processing >> Signal transduction >> FoxO signaling pathway;Environmental Information Processing >> Signal transduction >> AMPK signaling pathway |
| Research Areas | >>FoxO signaling pathway; / >>AMPK signaling pathway; / >>Longevity regulating pathway; / >>Longevity regulating pathway - multiple species; / >>Apelin signaling pathway; / >>Tight junction; / >>Circadian rhythm; / >>Thermogenesis; / >>Insulin signaling pathway; / >>Adipocytokine signaling pathway; / >>Oxytocin signaling pathway; / >>Glucagon signaling pathway; / >>Insulin resistance; / >>Non-alcoholic fatty liver disease; / >>Alcoholic liver disease; / >>Hypertrophic cardiomyopathy |
| Function | Function:AMPK is responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. Also regulates cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase and hormone-sensitive lipase. This is a regulatory subunit, may be a positive regulator of AMPK activity. It may also serve as an adapter molecule for the catalytic alpha-subunit.,PTM:Phosphorylated when associated with the catalytic subunit.,similarity:Belongs to the 5'-AMP-activated protein kinase beta subunit family.,subunit:Heterotrimer of an alpha catalytic subunit, a beta and a gamma non-catalytic regulatory subunits., |
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