SKU: WP11040 Categories: ,

AMY-1 Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11040-100
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Product details

Background:

The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011],

Specifications

Size50μL/100μL
TargetAMY-1
ReactivityHuman, Mouse
ApplicationsIHC, IF, ELISA
MW(Calculated)12kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioIHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from AMY-1 . at AA range: 30-110
SpecificityAMY-1 Polyclonal Antibody detects endogenous levels of AMY-1 protein.
Gene NameMYCBP
Protein NameC-Myc-binding protein
Other NameMYCBP; / AMY1; / C-Myc-binding protein; / Associate of Myc 1; / AMY-1
SpeciesHuman
Gene ID26292
UniprotQ99417,
Species.1Mouse
Gene ID.1
Uniprot.1Q9EQS3
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationCytoplasm. Nucleus. Mitochondrion. Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
Tissue ExpressionHighly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
Signaling_pathway
Research Areas
FunctionFunction:May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.,similarity:Belongs to the AMY1 family.,subcellular location:Translocates into the nucleus in the S phase of the cell cycle upon an increase of c-Myc expression. Found in the mitochondria when associated with AKAP1.,subunit:Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.,tissue specificity:Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.,
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