AMY-1 Polyclonal Antibody
Ucallm_WP11040-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011],
Specifications
| Size | 50μL/100μL |
| Target | AMY-1 |
| Reactivity | Human, Mouse |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 12kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from AMY-1 . at AA range: 30-110 |
| Specificity | AMY-1 Polyclonal Antibody detects endogenous levels of AMY-1 protein. |
| Gene Name | MYCBP |
| Protein Name | C-Myc-binding protein |
| Other Name | MYCBP; / AMY1; / C-Myc-binding protein; / Associate of Myc 1; / AMY-1 |
| Species | Human |
| Gene ID | 26292 |
| Uniprot | Q99417, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9EQS3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. Mitochondrion. Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1. |
| Tissue Expression | Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.,similarity:Belongs to the AMY1 family.,subcellular location:Translocates into the nucleus in the S phase of the cell cycle upon an increase of c-Myc expression. Found in the mitochondria when associated with AKAP1.,subunit:Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.,tissue specificity:Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung., |
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