Amylin Polyclonal Antibody
Ucallm_WP11042-50
Price range: $268.00 through $328.00
Product details
Background:
islet amyloid polypeptide(IAPP) Homo sapiens This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016],
Specifications
| Size | 50μL/100μL |
| Target | Amylin |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 25kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Amylin. AA range:1-50 |
| Specificity | Amylin Polyclonal Antibody detects endogenous levels of Amylin protein. |
| Gene Name | IAPP |
| Protein Name | Islet amyloid polypeptide |
| Other Name | IAPP; / Islet amyloid polypeptide; / Amylin; / Diabetes-associated peptide; / DAP; / Insulinoma amyloid peptide |
| Species | Human |
| Gene ID | 3375 |
| Uniprot | P10997, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P12968 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Secreted . |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>Neuroactive ligand-receptor interaction; / >>Maturity onset diabetes of the young |
| Function | Disease:IAPP is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas.,Function:Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.,online information:Amylin entry,similarity:Belongs to the calcitonin family., |
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