Product details
Background:
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ANKS1B rabbit pAb
Ucallm_WP8834-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ANKS1B |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 137kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ANKS1B |
| Specificity | This antibody detects endogenous levels of ANKS1B at Human, Mouse,Rat |
| Gene Name | ANKS1B |
| Protein Name | Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) |
| Other Name | |
| Species | Human |
| Gene ID | 56899 |
| Uniprot | Q7Z6G8, |
| Species.1 | Mouse |
| Gene ID.1 | 77531 |
| Uniprot.1 | Q8BIZ1, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P0C6S7 |
| Cellular Localization | Cytoplasm .; [Isoform 2]: Nucleus.; [Isoform 3]: Cell junction, synapse, postsynaptic density. Cell projection, dendritic spine. Nucleus. Nucleus, Cajal body. The synaptic localization requires DLG4 interaction. Translocation to the nucleus in response to stimulation of NMDA receptors (NMDARs) in a calcium-independent manner (By similarity). .; [Isoform 4]: Nucleus. The interaction with APP causes its partial exclusion from the nucleus, when APP is overexpressed.; [Isoform 6]: Nucleus. |
| Tissue Expression | Highly expressed in marrow from patients with pre-B ALL associated with the t(1; 19) translocation. Strongly expressed in brain and testis. Expressed in fetal brain. Isoform 4 is highly expressed in brain (at protein level). Isoform 6 is expressed in brain and several cancer cell lines. |
| Signaling_pathway | |
| Research Areas | |
| Function | Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.; Isoform 4 may play a role as a modulator of APP processing. Overexpression can down-regulate APP processing. |
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