Price range: $268.00 through $328.00
Background:
This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014],
| Specification | 50μL;100μL |
| Target | Annexin I |
| Reactivity | Human, Mouse, Rat, Monkey |
| Applications | WB |
| MW(Calculated) | |
| MW(Observed) | 38kD |
| Host Species | Mouse |
| Isotype | |
| Conjugate | |
| Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000 |
| Composition | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification Process | The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen. |
| Puity | |
| Storage Condition | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | |
| Immunogen | Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli. |
| Sequence | |
| Specificity | This antibody detects endogenous levels of Annexin A1 and does not cross-react with related proteins. |
| Gene Name | anxa1 |
| Protein Name | |
| Alias | Annexin 1;Annexin A1;Annexin I;lipocortin I;Annexin I;Annexin-1;AnnexinA1;AnnexinI;ANX 1;ANX A1;ANX1;ANXA 1;ANXA1;ANXA1 protein;ANXA1_HUMAN;Calpactin 2;Calpactin II;Calpactin-2;CalpactinII;Chromobindin 9;Chromobindin-9;Chromobindin9;HGNC:533;Lipocortin 1;Lipocortin I;Lipocortin1;LipocortinI;LPC 1;LPC1;p35;Phospholipase A2 inhibitory protein. |
| Organism-1 | Human |
| Gene ID-1 | 301 |
| SwissProt-1 | P04083 |
| Organism-2 | Mouse |
| Gene ID-2 | |
| SwissProt-2 | P10107 |
| Organism-3 | |
| Gene ID-3 | |
| SwissProt-3 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Cellular Localization | Nucleus . Cytoplasm . Cell projection, cilium . Cell membrane . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Basolateral cell membrane . Apical cell membrane . Lateral cell membrane . Secreted . Secreted, extracellular space . Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular exosome . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, phagocytic cup . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in the protein translocation from the cytoplasm into ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). Detected in gelatinase granules in resting neutrophils (PubMed:10772777). Secretion is increased in response to wounding and inflammation (PubMed:25664854). Secretion is increased upon T-cell activation (PubMed:17008549). Neutrophil adhesion to endothelial cells stimulates secretion via gelatinase granules, but foreign particle phagocytosis has no effect (PubMed:10772777). Colocalizes with actin fibers at phagocytic cups (By similarity). Displays calcium-dependent binding to phospholipid membranes (PubMed:2532504, PubMed:8557678). . |
