Annexin II [PTR1321] mouse mAb
Ucallm_WM1357-50
Price range: $268.00 through $328.00
Product details
Background:
annexin A2(ANXA2) Homo sapiens This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Annexin II |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IF, ELISA |
| MW(Calculated) | 38kD |
| MW(Observed) | 37kD |
| Host Species | Mouse |
| Isotype | IgG3,Kappa |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; IF 1:100-500; ELISA 1:1000-5000 |
| Formulation | PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA |
| Purification | Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein G affinity chromatography. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Monoclonal |
| Clone Number | RMMR1321 |
| Immunogen | Synthesized peptide derived from human protein. AA range: 100-200 |
| Specificity | This antibody detects endogenous levels of Annexin II protein. |
| Gene Name | ANXA2 ANX2 ANX2L4 CAL1H LPC2D |
| Protein Name | Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36) |
| Other Name | Annexin A2; / Annexin II; / Annexin-2; / Calpactin I heavy chain; / Calpactin-1 heavy chain; / Chromobindin-8; / Lipocortin II; / Placental anticoagulant protein IV; / PAP-IV; / Protein I; / p36 |
| Species | Human |
| Gene ID | 302 |
| Uniprot | P07355, |
| Species.1 | Mouse |
| Gene ID.1 | 12306 |
| Uniprot.1 | P07356 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasmic |
| Tissue Expression | |
| Signaling_pathway | |
| Research Areas | >>RNA degradation |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 . |
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