Product details
Background:
- Please choose product options by visiting TMC1 rabbit pAb.
- Please choose product options by visiting TM86B rabbit pAb.
ANO6 rabbit pAb
Ucallm_WP8918-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ANO6 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 100kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ANO6 |
| Specificity | This antibody detects endogenous levels of ANO6 at Human, Mouse |
| Gene Name | ANO6 TMEM16F |
| Protein Name | Anoctamin-6 (Transmembrane protein 16F) |
| Other Name | |
| Species | Human |
| Gene ID | 196527 |
| Uniprot | Q4KMQ2, |
| Species.1 | Mouse |
| Gene ID.1 | 105722 |
| Uniprot.1 | Q6P9J9 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cell membrane; Multi-pass membrane protein . Shows an intracellular localization according to PubMed:22075693. |
| Tissue Expression | Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer. |
| Signaling_pathway | |
| Research Areas | |
| Function | Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.; Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia. |
Please login to post questions
Related products
