Price range: $268.00 through $328.00
Background:
This gene encodes a subunit of the heterotetrameric adaptor-related protein comlex 1 (AP-1), which belongs to the adaptor complexes medium subunits family. This protein is capable of interacting with tyrosine-based sorting signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | AP1M2 |
| Reactivity | Human, Mouse |
| Applications | WB |
| MW(Calculated) | 47kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AP1M2 AA range: 117-167 |
| Specificity | This antibody detects endogenous levels of AP1M2 at Human/Mouse |
| Gene Name | AP1M2 |
| Protein Name | AP1M2 |
| Other Name | |
| Species | Human |
| Gene ID | 10053 |
| Uniprot | Q9Y6Q5, |
| Species.1 | Mouse |
| Gene ID.1 | 11768 |
| Uniprot.1 | Q9WVP1 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex. |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | >>Lysosome; / >>Human immunodeficiency virus 1 infection |
| Function | Function:Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.,PTM:Phosphorylation of membrane-bound AP1M1/AP1M2 increases its affinity for sorting signals.,similarity:Belongs to the adaptor complexes medium subunit family.,similarity:Contains 1 MHD (mu homology) domain.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.,subunit:Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3)., |
