AP2B1 rabbit pAb
Ucallm_WP16502-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | AP2B1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 103kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AP2B1 AA range: 70-120 |
| Specificity | This antibody detects endogenous levels of AP2B1 at Human/Mouse/Rat |
| Gene Name | AP2B1 ADTB2 CLAPB1 |
| Protein Name | AP2B1 |
| Other Name | |
| Species | Human |
| Gene ID | 163 |
| Uniprot | P63010, |
| Species.1 | Mouse |
| Gene ID.1 | 71770 |
| Uniprot.1 | Q9DBG3, |
| Species.2 | Rat |
| Gene ID.2 | 100912146 |
| Uniprot.2 | P62944 |
| Cellular Localization | Cell membrane . Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side . AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. |
| Tissue Expression | Expressed in the brain (at protein level). |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Neurodegenerative disease >> Huntington disease |
| Research Areas | >>Endocytosis; / >>Synaptic vesicle cycle; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Huntington disease |
| Function | Function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2B1 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.,similarity:Belongs to the adaptor complexes large subunit family.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.,subunit:Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1). Binds EPN1, EPS15, SNAP91 and clathrin., |
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