Price range: $268.00 through $328.00
Background:
One of two major clathrin-associated adaptor complexes, AP-2, is a heterotetramer which is associated with the plasma membrane. This complex is composed of two large chains, a medium chain, and a small chain. This gene encodes the small chain of this complex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
| Size | 50μL/100μL |
| Target | AP2S1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 16kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human AP2S1 AA range: 26-76 |
| Specificity | This antibody detects endogenous levels of AP2S1 at Human/Mouse/Rat |
| Gene Name | AP2S1 AP17 CLAPS2 |
| Protein Name | AP2S1 |
| Other Name | |
| Species | Human |
| Gene ID | 1175 |
| Uniprot | P53680, |
| Species.1 | Mouse |
| Gene ID.1 | 232910 |
| Uniprot.1 | P62743, |
| Species.2 | Rat |
| Gene ID.2 | 65046 |
| Uniprot.2 | P62744 |
| Cellular Localization | Cell membrane. Membrane, coated pit; Peripheral membrane protein; Cytoplasmic side. AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV. . |
| Tissue Expression | |
| Signaling_pathway | Organismal Systems >> Nervous system >> Synaptic vesicle cycle;Human Diseases >> Neurodegenerative disease >> Huntington disease |
| Research Areas | >>Endocytosis; / >>Synaptic vesicle cycle; / >>Endocrine and other factor-regulated calcium reabsorption; / >>Huntington disease |
| Function | Function:Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration. AP2S1/AP17 is a subunit of the plasma membrane adaptor. The complex binds polyphosphoinositides.,similarity:Belongs to the adaptor complexes small subunit family.,subcellular location:Component of the coat surrounding the cytoplasmic face of coated vesicles in the plasma membrane.,subunit:Adaptor protein complex 2 (AP-2) is an heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1)., |
