Price range: $268.00 through $328.00
Background:
This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008],
| Size | 50μL/100μL |
| Target | APOA2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 11kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from part region of human protein AA range: 1-50 |
| Specificity | APOA2 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | APOA2 |
| Protein Name | Apolipoprotein A-II (Apo-AII) (ApoA-II) (Apolipoprotein A2) [Cleaved into: Truncated apolipoprotein A-II (Apolipoprotein A-II(1-76))] |
| Other Name | |
| Species | Human |
| Gene ID | 336 |
| Uniprot | P02652, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | P09813, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | P04638 |
| Cellular Localization | Secreted . |
| Tissue Expression | Plasma; synthesized in the liver and intestine. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> PPAR signaling pathway |
| Research Areas | >>PPAR signaling pathway; / >>Cholesterol metabolism |
| Function | Function:May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism.,mass spectrometry: PubMed:12562854,mass spectrometry:Cysteinylated ApoA-II PubMed:12562854,mass spectrometry:Heterodimer with apolipoprotein A-II(1-76) PubMed:12562854,mass spectrometry:Homodimer PubMed:12562854,online information:The Singapore human mutation and polymorphism database,similarity:Belongs to the apolipoprotein A2 family.,subunit:Homodimer; disulfide-linked. Also forms a disulfide-linked heterodimer with APOD. Interacts with HCV core protein. Interacts with APOA1BP.,tissue specificity:Plasma; synthesized in the liver and intestine., |
