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ApoL3 Polyclonal Antibody
Ucallm_WP11084-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015],
Specifications
| Size | 50μL/100μL |
| Target | ApoL3 |
| Reactivity | Human |
| Applications | IHC, IF, ELISA |
| MW(Calculated) | 44kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from ApoL3 . at AA range: 100-180 |
| Specificity | ApoL3 Polyclonal Antibody detects endogenous levels of ApoL3 protein. |
| Gene Name | APOL3 |
| Protein Name | Apolipoprotein L3 |
| Other Name | APOL3; / Apolipoprotein L3; / Apolipoprotein L-III; / ApoL-III; / TNF-inducible protein CG12-1; / CG12_1 |
| Species | Human |
| Gene ID | 80833 |
| Uniprot | O95236 |
| Species.1 | |
| Gene ID.1 | |
| Uniprot.1 | |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.,induction:In vitro, is responsive to tumor necrosis factor.,similarity:Belongs to the apolipoprotein L family.,tissue specificity:Widely expressed; the highest levels are in prostate, lung and placenta; also detected in kidney, bone marrow, spleen, thymus, spinal cord, adrenal gland, salivary gland, trachea and mammary gland; levels are low in brain, heart, fetal liver, pancreas and testis., |
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