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ApoO Monoclonal Antibody
Ucallm_WM0034-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009],
Specifications
| Size | 50μL/100μL |
| Target | ApoO |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | 22kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:200-1:1000; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 9C12 |
| Immunogen | Purified recombinant fragment of ApoO expressed in E. Coli. |
| Specificity | ApoO Monoclonal Antibody detects endogenous levels of ApoO protein. |
| Gene Name | APOO |
| Protein Name | Apolipoprotein O |
| Other Name | APOO; / FAM121B; / My025; / Apolipoprotein O; / Protein FAM121B |
| Species | Human |
| Gene ID | 79135 |
| Uniprot | Q9BUR5, |
| Species.1 | Mouse |
| Gene ID.1 | 68316 |
| Uniprot.1 | Q9DCZ4 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Mitochondrion inner membrane; Single-pass membrane protein . Secreted . Mitochondrion . Golgi apparatus membrane . Endoplasmic reticulum membrane . Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. . |
| Tissue Expression | Expressed in all tissues examined. Up-regulated in diabetic heart. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.,PTM:O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.,similarity:Belongs to the apolipoprotein O family.,tissue specificity:Expressed in all tissues examined. Up-regulated in diabetic heart., |
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