SKU: WP17196 Categories: ,

ARC1B rabbit pAb

Price range: $268.00 through $328.00

SKU: WP17196-100
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Product details

Background:

This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011],

Specifications

Size50μL/100μL
TargetARC1B
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)41kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ARC1B AA range: 27-77
SpecificityThis antibody detects endogenous levels of ARC1B at Human/Mouse/Rat
Gene NameARPC1B ARC41
Protein NameARC1B
Other Name
SpeciesHuman
Gene ID10095
UniprotO15143,
Species.1Mouse
Gene ID.111867
Uniprot.1Q9WV32,
Species.2Rat
Gene ID.254227
Uniprot.2O88656
Cellular LocalizationCytoplasm, cytoskeleton . Nucleus .
Tissue Expression
Signaling_pathwayCellular Processes >> Cellular community - eukaryotes >> Tight junction;Cellular Processes >> Cell motility >> Regulation of actin cytoskeleton;Organismal Systems >> Immune system >> Fc gamma R-mediated phagocytosis
Research Areas>>Endocytosis; / >>Tight junction; / >>Fc gamma R-mediated phagocytosis; / >>Regulation of actin cytoskeleton; / >>Bacterial invasion of epithelial cells; / >>Pathogenic Escherichia coli infection; / >>Shigellosis; / >>Salmonella infection; / >>Yersinia infection
FunctionFunction:Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.,similarity:Belongs to the WD repeat ARPC1 family.,similarity:Contains 6 WD repeats.,subunit:Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.,
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