Price range: $268.00 through $328.00
Background:
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein contains a SRC homology 3 domain and interacts with Bcl-2-associated protein family members. [provided by RefSeq, Aug 2012],
| Size | 50μL/100μL |
| Target | ARHGAP1 |
| Reactivity | Human, Mouse |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 50kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:10000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human RHG1. AA range:189-238 |
| Specificity | ARHGAP1 Polyclonal Antibody detects endogenous levels of ARHGAP1 protein. |
| Gene Name | ARHGAP1 |
| Protein Name | Rho GTPase-activating protein 1 |
| Other Name | ARHGAP1; / CDC42GAP; / RHOGAP1; / Rho GTPase-activating protein 1; / CDC42 GTPase-activating protein; / GTPase-activating protein rhoOGAP; / Rho-related small GTPase protein activator; / Rho-type GTPase-activating protein 1; / p50-RhoGAP |
| Species | Human |
| Gene ID | 392 |
| Uniprot | Q07960, |
| Species.1 | Mouse |
| Gene ID.1 | 228359 |
| Uniprot.1 | Q5FWK3 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:GTPase activator for the Rho, Rac and Cdc42 proteins, converting them to the putatively inactive GDP-bound state. Cdc42 seems to be the preferred substrate.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 Rho-GAP domain.,subunit:Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with BNIPL.,tissue specificity:Ubiquitous., |
