Name: ARK-2/3 (phospho Thr236/202) Polyclonal Antibody
SKU: WP10044
Price: 288 USD
Availability: InStock

ARK-2/3 (phospho Thr236/202) Polyclonal Antibody

Ucallm_WP10044-50

Price range: $288.00 through $368.00

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100μl

50μl

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SKU: WP10044-100

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Product details

Background:

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of alignment and segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015],

Specifications

Target	AurB/C
Reactivity	Human, Mouse, Rat
Applications	IHC, IF, ELISA
MW(Calculated)	35-40kD
MW(Observed)
Host Species	Rabbit
Isotype	IgG
Conjugate
Modification	Phospho
Recommended Dilution Ratio	IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Composition	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification Process	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity
Storage Condition	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human AurB/C around the phosphorylation site of Thr236/202. AA range:201-250
Sequence
Specificity	Phospho-ARK-2/3 (T236/202) Polyclonal Antibody detects endogenous levels of ARK-2/3 protein only when phosphorylated at T236/202.
Gene Name	AURKB/AURKC
Protein Name	Serine/threonine-protein kinase 12/Aurora kinase C
Alias	AURKB;AIK2;AIM1;AIRK2;ARK2;STK1;STK12;STK5;Aurora kinase B;Aurora 1;Aurora- and IPL1-like midbody-associated protein 1;AIM-1;Aurora/IPL1-related kinase 2;ARK-2;Aurora-related kinase 2;STK-1;Serine/threonine-protein kinase 12
Organism-1	Human
Gene ID-1	9212;6795
SwissProt-1	Q96GD4;Q9UQB9
Organism-2	Mouse
Gene ID-2	20877
SwissProt-2
Organism-3	Rat
Gene ID-3	114592
SwissProt-3	O55099
Organism-4
Gene ID-4
SwissProt-4
Cellular Localization	Nucleus . Chromosome . Chromosome, centromere . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Midbody . Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis (PubMed:20929775). Colocalized with gamma tubulin in the midbody (PubMed:17726514). Proper localization of the active, Thr-232-phosphorylated form during metaphase may be dependent upon interaction with SPDYC (PubMed:20605920). Colocalized with SIRT2 during cytokinesis with the midbody (PubMed:17726514). Localization (and probably targeting of the CPC) to the inner centromere occurs predominantly in regions with overlapping mitosis-specific histone phosphorylations H3pT3 and H2ApT12 (PubMed:20929775). .