Arrestin-β-1 Polyclonal Antibody
Ucallm_WP11143-50
Price range: $268.00 through $328.00
Product details
Background:
Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described. [provided by RefSeq, Jan 2011],
Specifications
| Size | 50μL/100μL |
| Target | Arrestin 1 |
| Reactivity | Human, Monkey |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 47kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:10000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human Arrestin 1. AA range:369-418 |
| Specificity | Arrestin-β-1 Polyclonal Antibody detects endogenous levels of Arrestin-β-1 protein. |
| Gene Name | ARRB1 |
| Protein Name | Beta-arrestin-1 |
| Other Name | ARRB1; / ARR1; / Beta-arrestin-1; / Arrestin beta-1 |
| Species | Human |
| Gene ID | 408 |
| Uniprot | P49407, |
| Species.1 | Mouse |
| Gene ID.1 | 109689 |
| Uniprot.1 | Q8BWG8 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cell projection, pseudopodium . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs. The monomeric form is predominantly located in the nucleus. The oligomeric form is located in the cytoplasm. Translocates to the nucleus upon stimulation of OPRD1 (By similarity). . |
| Tissue Expression | Brain,Peripheral blood,Uterus, |
| Signaling_pathway | Organismal Systems >> Immune system >> Chemokine signaling pathway;Organismal Systems >> Endocrine system >> Relaxin signaling pathway;Organismal Systems >> Nervous system >> Dopaminergic synapse;Environmental Information Processing >> Signal transduction >> MAPK signaling pathway;Environmental Information Processing >> Signal transduction >> Hedgehog signaling pathway |
| Research Areas | >>MAPK signaling pathway; / >>Chemokine signaling pathway; / >>Endocytosis; / >>Hedgehog signaling pathway; / >>Dopaminergic synapse; / >>Olfactory transduction; / >>Relaxin signaling pathway; / >>Parathyroid hormone synthesis, secretion and action; / >>GnRH secretion; / >>Morphine addiction; / >>Chemical carcinogenesis - receptor activation |
| Function | Function:Regulates beta-adrenergic receptor function. Beta-arrestins seem to bind phosphorylated beta-adrenergic receptors, thereby causing a significant impairment of their capacity to activate G(S) proteins.,online information:Arrestin entry,similarity:Belongs to the arrestin family., |
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