Price range: $268.00 through $328.00
Background:
The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016],
| Target | Arrestin-C |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 40kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Modification | |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; IF 1:200-1:1000; ELISA 1:5000; Not yet tested in other applications. / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#YS0004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Source | |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Purity | |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARRC. AA range:339-388 |
| Sequence | |
| Specificity | Arrestin-C Polyclonal Antibody detects endogenous levels of Arrestin-C protein. |
| Gene Name | ARR3 |
| Protein Name | Arrestin-C |
| Other Name | ARR3; / ARRX; / CAR; / Arrestin-C; / Cone arrestin; / C-arrestin; / cArr; / Retinal cone arrestin-3; / X-arrestin |
| Species | Human |
| Gene ID-1 | 407 |
| Uniprot | P36575, |
| Species.1 | Mouse |
| Gene ID-2 | |
| Uniprot.1 | Q9EQP6 |
| Species.2 | |
| Gene ID-3 | |
| Uniprot.2 | |
| Organism-4 | |
| Gene ID-4 | |
| SwissProt-4 | |
| Background | The protein encoded by this gene is a non-visual arrestin which binds to agonist-activated, phosphorylated G protein-coupled receptors. This binding uncouples the receptor from the heterotrimeric G protein, resulting in termination of the G protein-coupled receptor signaling. The encoded protein also is a part of the centrosome, interacting with gamma-tubulin to help regulate proper centrosome function. [provided by RefSeq, May 2016], |
| Cellular Localization | Photoreceptor inner segment . Cell projection, cilium, photoreceptor outer segment . |
| Tissue Expression | Inner and outer segments, and the inner plexiform regions of the retina. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:May play a role in an as yet undefined retina-specific signal transduction. Could binds to photoactivated-phosphorylated red/green opsins.,similarity:Belongs to the arrestin family.,tissue specificity:Inner and outer segments, and the inner plexiform regions of the retina., |
| RRID |
