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Home/Reagents/Antibody/Primary antibody/Polyclonal Antibody/Rabbit pAb/Arylsulfatase E Polyclonal Antibody
SKU: WP11149 Categories: ,

Arylsulfatase E Polyclonal Antibody

Ucallm_WP11149-50

Price range: $268.00 through $328.00

SKU: WP11149-100
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Product details

Background:

Arylsulfatase E is a member of the sulfatase family. It is glycosylated postranslationally and localized to the golgi apparatus. Sulfatases are essential for the correct composition of bone and cartilage matrix. X-linked chondrodysplasia punctata, a disease characterized by abnormalities in cartilage and bone development, has been linked to mutations in this gene. Alternative splicing results in multiple transcript variants. A pseudogene related to this gene is located on the Y chromosome. [provided by RefSeq, Sep 2013],

Specifications

Size50μL/100μL
TargetArylsulfatase E
ReactivityHuman
ApplicationsWB, ELISA
MW(Calculated)
MW(Observed)65kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; ELISA 1:10000; Not yet tested in other applications.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from Arylsulfatase E . at AA range: 120-200
SpecificityArylsulfatase E Polyclonal Antibody detects endogenous levels of Arylsulfatase E protein.
Gene NameARSE
Protein NameArylsulfatase E
Other NameARSE; / Arylsulfatase E; / ASE
SpeciesHuman
Gene ID415
UniprotP51690
Species.1
Gene ID.1
Uniprot.1
Species.2
Gene ID.2
Uniprot.2
Cellular LocalizationGolgi apparatus, Golgi stack .
Tissue ExpressionExpressed in the pancreas, liver and kidney.
Signaling_pathway
Research Areas
Functioncofactor:Binds 1 calcium ion per subunit.,Disease:Defects in ARSE are the cause of chondrodysplasia punctata X-linked recessive type 1 (CDPX1) [MIM:302950]. CDP is a clinically and genetically heterogeneous disorder characterized by punctiform calcification of the bones. CDPX1 is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. This disease can also be induced by inhibition with the drug warfarin.,enzyme regulation:Inhibited by millimolar concentrations of warfarin.,Function:May be essential for the correct composition of cartilage and bone matrix during development. Has no activity toward steroid sulfates.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Expressed in the pancreas, liver and kidney.,
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