SKU: WP11151 Categories: ,

Arylsulfatase G Polyclonal Antibody

Price range: $268.00 through $328.00

SKU: WP11151-100
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Product details

Background:

The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],

Specifications

Size50μL/100μL
TargetArylsulfatase G
ReactivityHuman, Mouse, Rat
ApplicationsWB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)65kD
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenThe antiserum was produced against synthesized peptide derived from human ARSG. AA range:251-300
SpecificityArylsulfatase G Polyclonal Antibody detects endogenous levels of Arylsulfatase G protein.
Gene NameARSG
Protein NameArylsulfatase G
Other NameARSG; / KIAA1001; / Arylsulfatase G; / ASG
SpeciesHuman
Gene ID22901
UniprotQ96EG1,
Species.1Mouse
Gene ID.174008
Uniprot.1Q3TYD4,
Species.2Rat
Gene ID.2303631
Uniprot.2Q32KJ9
Cellular LocalizationLysosome . The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. .
Tissue ExpressionWidely expressed, with very low expression in brain, lung, heart and skeletal muscle.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Lysosome
Research Areas>>Lysosome
Functioncofactor:Binds 1 calcium ion per subunit.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Widely expressed.,
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