Arylsulfatase G Polyclonal Antibody
Ucallm_WP11151-50
Price range: $268.00 through $328.00
Product details
Background:
The protein encoded by this gene belongs to the sulfatase enzyme family. Sulfatases hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012],
Specifications
| Size | 50μL/100μL |
| Target | Arylsulfatase G |
| Reactivity | Human, Mouse, Rat |
| Applications | WB, IHC, IF, ELISA |
| MW(Calculated) | |
| MW(Observed) | 65kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:40000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human ARSG. AA range:251-300 |
| Specificity | Arylsulfatase G Polyclonal Antibody detects endogenous levels of Arylsulfatase G protein. |
| Gene Name | ARSG |
| Protein Name | Arylsulfatase G |
| Other Name | ARSG; / KIAA1001; / Arylsulfatase G; / ASG |
| Species | Human |
| Gene ID | 22901 |
| Uniprot | Q96EG1, |
| Species.1 | Mouse |
| Gene ID.1 | 74008 |
| Uniprot.1 | Q3TYD4, |
| Species.2 | Rat |
| Gene ID.2 | 303631 |
| Uniprot.2 | Q32KJ9 |
| Cellular Localization | Lysosome . The 63-kDa precursor protein localizes to pre-lysosomal compartments and tightly associates with organelle membranes, most likely the endoplasmic reticulum. In contrast, proteolytically processed fragments of 34-, 18- and 10-kDa are found in lysosomal fractions and lose their membrane association. . |
| Tissue Expression | Widely expressed, with very low expression in brain, lung, heart and skeletal muscle. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Lysosome |
| Research Areas | >>Lysosome |
| Function | cofactor:Binds 1 calcium ion per subunit.,PTM:N-glycosylated.,PTM:The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.,similarity:Belongs to the sulfatase family.,tissue specificity:Widely expressed., |
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