Price range: $268.00 through $328.00
Background:
This gene encodes a protein that belongs to a family of helicases that are involved in the ATP-dependent unwinding of nucleic acid duplexes. The encoded protein is the largest subunit of the activating signal cointegrator 1 complex that is involved in DNA repair and resistance to alkylation damage. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013],
| Size | 50μL/100μL |
| Target | ASCC3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 242kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ASCC3 AA range: 2053-2103 |
| Specificity | This antibody detects endogenous levels of ASCC3 at Human/Mouse/Rat |
| Gene Name | ASCC3 HELIC1 |
| Protein Name | ASCC3 |
| Other Name | |
| Species | Human |
| Gene ID | 10973 |
| Uniprot | Q8N3C0, |
| Species.1 | Mouse |
| Gene ID.1 | 77987 |
| Uniprot.1 | E9PZJ8, |
| Species.2 | Rat |
| Gene ID.2 | |
| Uniprot.2 | F1LPQ2 |
| Cellular Localization | Nucleus . Nucleus speckle . Cytoplasm, cytosol . Colocalizes with ALKBH3 and ASCC2 in nuclear foci when cells have been exposed to alkylating agents that cause DNA damage. . |
| Tissue Expression | Ubiquitous. |
| Signaling_pathway | |
| Research Areas | |
| Function | Function:Enhances NF-kappa-B, SRF and AP1 transactivation.,similarity:Belongs to the helicase family.,similarity:Contains 2 helicase ATP-binding domains.,similarity:Contains 2 helicase C-terminal domains.,similarity:Contains 3 SEC63 domains.,subunit:Part of TRIP4 complex, that contains ASCC1, ASCC2 and ASCC3.,tissue specificity:Ubiquitous., |
