Price range: $268.00 through $328.00
Background:
This gene encodes an arginyltransferase, an enzyme that is involved in posttranslational conjugation of arginine to N-terminal aspartate or glutamate residues. Conjugation of arginine to the N-terminal aspartate or glutamate targets proteins for ubiquitin-dependent degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013],
| Size | 50μL/100μL |
| Target | ATE1 |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 56kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000; ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human protein . at AA range: 400-480 |
| Specificity | ATE1 Polyclonal Antibody detects endogenous levels of protein. |
| Gene Name | ATE1 |
| Protein Name | Arginyl-tRNA--protein transferase 1 (Arginyltransferase 1) (R-transferase 1) (Arginine-tRNA--protein transferase 1) |
| Other Name | |
| Species | Human |
| Gene ID | 11101 |
| Uniprot | O95260, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q9Z2A5 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | [Isoform ATE1-1]: Nucleus . Cytoplasm .; [Isoform ATE1-2]: Cytoplasm . |
| Tissue Expression | Embryonic kidney,Testis, |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalytic activity:L-arginyl-tRNA + protein = tRNA + L-arginyl-protein.,Caution:It is uncertain whether Met-1 or Met-37 is the initiator.,Function:Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. Does not arginylate cysteine residues.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the R-transferase family.,subunit:Monomer ., |
