Product details
Background:
miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry.,
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ATG14L Rabbit Polyclonal Antibody
Ucallm_WP5917-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ATG14 |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 55kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Recombinant Protein of ATG14L |
| Specificity | The antibody detects endogenous ATG14L protein |
| Gene Name | ATG14 KIAA0831 ATG14L |
| Protein Name | Beclin 1-associated autophagy-related key regulator (Barkor) (Autophagy-related protein 14-like protein) (Atg14L) |
| Other Name | Beclin 1-associated autophagy-related key regulator; / Barkor; / Autophagy-related protein 14-like protein; / Atg14L |
| Species | Human |
| Gene ID | 22863 |
| Uniprot | Q6ZNE5, |
| Species.1 | Mouse |
| Gene ID.1 | 100504663 |
| Uniprot.1 | Q8CDJ3, |
| Species.2 | Rat |
| Gene ID.2 | 305831 |
| Uniprot.2 | D4A4K3 |
| Cellular Localization | Cytoplasm . Endoplasmic reticulum membrane; Peripheral membrane protein . Preautophagosomal structure membrane; Peripheral membrane protein . Cytoplasmic vesicle, autophagosome membrane; Peripheral membrane protein . Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). . |
| Tissue Expression | Brain,Epithelium,Hippocampus,Trachea, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases |
| Research Areas | >>Autophagy - animal; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection |
| Function | miscellaneous:The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry., |
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