SKU: WP16551 Categories: ,

ATG3 rabbit pAb

Price range: $268.00 through $328.00

SKU: WP16551-100
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Product details

Background:

This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],

Specifications

Size50μL/100μL
TargetATG3
ReactivityHuman, Mouse, Rat
ApplicationsWB
MW(Calculated)35kD
MW(Observed)
Host SpeciesRabbit
IsotypeIgG
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:500-2000
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityPolyclonal
Clone Number
ImmunogenSynthesized peptide derived from human ATG3 AA range: 28-78
SpecificityThis antibody detects endogenous levels of ATG3 at Human/Mouse/Rat
Gene NameATG3 APG3 APG3L
Protein NameATG3
Other Name
SpeciesHuman
Gene ID64422
UniprotQ9NT62,
Species.1Mouse
Gene ID.167841
Uniprot.1Q9CPX6,
Species.2Rat
Gene ID.2171415
Uniprot.2Q6AZ50
Cellular LocalizationCytoplasm .
Tissue ExpressionWidely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal
Research Areas>>Autophagy - other; / >>Autophagy - animal; / >>Kaposi sarcoma-associated herpesvirus infection
FunctionFunction:GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG3 family.,subunit:Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta.,
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