ATG3 rabbit pAb
Ucallm_WP16551-50
Price range: $268.00 through $328.00
Product details
Background:
This gene encodes a ubiquitin-like-conjugating enzyme and is a component of ubiquitination-like systems involved in autophagy, the process of degradation, turnover and recycling of cytoplasmic constituents in eukaryotic cells. This protein is known to play a role in regulation of autophagy during cell death. A pseudogene of this gene is located on chromosome 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | ATG3 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 35kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ATG3 AA range: 28-78 |
| Specificity | This antibody detects endogenous levels of ATG3 at Human/Mouse/Rat |
| Gene Name | ATG3 APG3 APG3L |
| Protein Name | ATG3 |
| Other Name | |
| Species | Human |
| Gene ID | 64422 |
| Uniprot | Q9NT62, |
| Species.1 | Mouse |
| Gene ID.1 | 67841 |
| Uniprot.1 | Q9CPX6, |
| Species.2 | Rat |
| Gene ID.2 | 171415 |
| Uniprot.2 | Q6AZ50 |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta. |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal |
| Research Areas | >>Autophagy - other; / >>Autophagy - animal; / >>Kaposi sarcoma-associated herpesvirus infection |
| Function | Function:GABARAPL1 (GABARAPL2 or GABARAP or MAP1LC3)-modifier protein conjugating enzyme involved in its E2-like covalent binding to PE. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3 (E2-like enzyme). Preferred substrate is MAP1LC3A. Formation of the GABARAPL1-PE conjugate is essential for autophagy.,similarity:Belongs to the ATG3 family.,subunit:Interacts with ATG7 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.,tissue specificity:Widely expressed, with a highest expression in heart, skeletal muscle, kidney, liver and placenta., |
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