Name: Atg4b Polyclonal Antibody
SKU: WP11192
Price: 268 USD
Availability: InStock

Atg4b Polyclonal Antibody

Ucallm_WP11192-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP11192-100

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Product details

Background:

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

Specifications

Size	50μL/100μL
Target	ATG4B
Reactivity	Human, Mouse
Applications	WB, IHC, IF, ELISA
MW(Calculated)
MW(Observed)	44kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; IHC 1:100-1:300; ELISA 1:20000; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	The antiserum was produced against synthesized peptide derived from human ATG4B. AA range:71-120
Specificity	Atg4b Polyclonal Antibody detects endogenous levels of Atg4b protein.
Gene Name	ATG4B APG4B AUTL1 KIAA0943
Protein Name	Cysteine protease ATG4B
Other Name	ATG4B; / APG4B; / AUTL1; / KIAA0943; / Cysteine protease ATG4B; / AUT-like 1 cysteine endopeptidase; / Autophagin-1; / Autophagy-related cysteine endopeptidase 1; / Autophagy-related protein 4 homolog B; / hAPG4B
Species	Human
Gene ID	23192
Uniprot	Q9Y4P1,
Species.1	Mouse
Gene ID.1	66615
Uniprot.1	Q8BGE6
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Cytoplasm . Cytoplasm, cytosol . Cytoplasmic vesicle, autophagosome . Endoplasmic reticulum . Mitochondrion . Mainly localizes to the cytoplasm, including cytosol (PubMed:29165041). A samll potion localizes to mitochondria; phosphorylation at Ser-34 promotes localization to mitochondria (PubMed:29165041). .
Tissue Expression	Brain,Embryo,Endometrium,Epithelium,Hippocampus,Liver,Placenta,Test
Signaling_pathway	Cellular Processes >> Transport and catabolism >> Autophagy - animal
Research Areas	>>Autophagy - other; / >>Autophagy - animal
Function	enzyme regulation:Inhibited by N-ethylmaleimide.,Function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Mainly expressed in the skeletal muscle, followed by brain, heart, liver and pancreas.,