ATG4c Rabbit Polyclonal Antibody
Ucallm_WP5914-50
Price range: $268.00 through $328.00
Product details
Background:
Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | ATG4C |
| Reactivity | Human, Mouse, Rat |
| Applications | IHC, IF |
| MW(Calculated) | |
| MW(Observed) | 57kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | IHC 1:50-300; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Recombinant Protein of ATG4c |
| Specificity | The antibody detects endogenous ATG4c protein |
| Gene Name | ATG4C APG4C AUTL1 AUTL3 |
| Protein Name | Cysteine protease ATG4C |
| Other Name | ATG4C; / APG4C; / AUTL1; / AUTL3; / Cysteine protease ATG4C; / AUT-like 3 cysteine endopeptidase; / Autophagin-3; / Autophagy-related cysteine endopeptidase 3; / Autophagy-related protein 4 homolog C |
| Species | Human |
| Gene ID | 84938 |
| Uniprot | Q96DT6, |
| Species.1 | Mouse |
| Gene ID.1 | |
| Uniprot.1 | Q811C2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Cytoplasm . |
| Tissue Expression | Brain,Heart,Placenta,Testis, |
| Signaling_pathway | Cellular Processes >> Transport and catabolism >> Autophagy - animal |
| Research Areas | >>Autophagy - other; / >>Autophagy - animal |
| Function | enzyme regulation:Inhibited by N-ethylmaleimide.,Function:Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.,similarity:Belongs to the peptidase C54 family.,tissue specificity:Highly expressed in skeletal muscle, heart, liver and testis., |
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