Product details
Background:
ATGL rabbit pAb
Ucallm_WP6000-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | PNPLA2 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 55kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ATGL |
| Specificity | This antibody detects endogenous levels of ATGL at Human, Mouse,Rat |
| Gene Name | PNPLA2 ATGL FP17548 |
| Protein Name | Patatin-like phospholipase domain-containing protein 2 (Adipose triglyceride lipase) (Calcium-independent phospholipase A2) (Desnutrin) (IPLA2-zeta) (Pigment epithelium-derived factor) (TTS2.2) (Transport-secretion protein 2) (TTS2) |
| Other Name | |
| Species | Human |
| Gene ID | 57104 |
| Uniprot | Q96AD5, |
| Species.1 | Mouse |
| Gene ID.1 | 66853 |
| Uniprot.1 | Q8BJ56, |
| Species.2 | Rat |
| Gene ID.2 | 100911615 |
| Uniprot.2 | P0C548 |
| Cellular Localization | Lipid droplet . Cell membrane; Multi-pass membrane protein . Cytoplasm . |
| Tissue Expression | Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level). |
| Signaling_pathway | |
| Research Areas | |
| Function | Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets . Exhibits a strong preference for the hydrolysis of long-chain fatty acid esters at the sn-2 position of the glycerol backbone and acts coordinately with LIPE/HLS and DGAT2 within the lipolytic cascade (By similarity). Also possesses acylglycerol transacylase and phospholipase A2 activities . Transfers fatty acid from triglyceride to retinol, hydrolyzes retinylesters, and generates 1,3-diacylglycerol from triglycerides . Regulates adiposome size and may be involved in the degradation of adiposomes . May play an important role in energy homeostasis (By similarity). May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion (By similarity). |
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