ATP-citrate synthase Monoclonal Antibody
Ucallm_WM0476-50
Price range: $268.00 through $328.00
Product details
Background:
ATP citrate lyase(ACLY) Homo sapiens ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440, 000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014],
Specifications
| Size | 50μL/100μL |
| Target | ATP-citrate synthase |
| Reactivity | Human, Mouse, Rat, Bovine, Chicken, Pig, sheep |
| Applications | WB, IF, FC |
| MW(Calculated) | 121kD |
| MW(Observed) | |
| Host Species | Mouse |
| Isotype | |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:1000-1:2000; IF 1:100-1:500; Flow Cyt 1:100-1:200; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | Affinity purification |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | |
| Clonality | Monoclonal |
| Clone Number | 17A2 |
| Immunogen | Purified recombinant human ATP-citrate Lyase (C-terminus) protein fragments expressed in E.coli. |
| Specificity | ATP-citrate Lyase Monoclonal Antibody detects endogenous levels of ATP-citrate Lyase protein. |
| Gene Name | ACLY |
| Protein Name | ATP-citrate synthase |
| Other Name | ACLY; / ATP-citrate synthase; / ATP-citrate; / pro-S-; / -lyase; / ACL; / Citrate cleavage enzyme |
| Species | Human |
| Gene ID | 47 |
| Uniprot | P53396, |
| Species.1 | Mouse |
| Gene ID.1 | 104112 |
| Uniprot.1 | Q91V92, |
| Species.2 | Rat |
| Gene ID.2 | 24159 |
| Uniprot.2 | P16638 |
| Cellular Localization | Cytoplasm, cytosol . |
| Tissue Expression | Brain,Epithelium,Hippocampus,Liver,Lymph,Platelet, |
| Signaling_pathway | |
| Research Areas | >>Citrate cycle (TCA cycle); / >>Metabolic pathways |
| Function | Catalytic activity:ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA.,Function:ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.,similarity:In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.,similarity:In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.,subunit:Homotetramer., |
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