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ATP1B1 rabbit pAb
Ucallm_WP6180-50
Price range: $268.00 through $328.00
Specifications
| Size | 50μL/100μL |
| Target | ATP1B1 |
| Reactivity | Human, Mouse, Rat |
| Applications | WB |
| MW(Calculated) | 33kD |
| MW(Observed) | |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human ATP1B1 |
| Specificity | This antibody detects endogenous levels of ATP1B1 at Human, Mouse,Rat |
| Gene Name | ATP1B1 ATP1B |
| Protein Name | Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1) |
| Other Name | |
| Species | Human |
| Gene ID | 481 |
| Uniprot | P05026, |
| Species.1 | Mouse |
| Gene ID.1 | 11931 |
| Uniprot.1 | P14094, |
| Species.2 | Rat |
| Gene ID.2 | 25650 |
| Uniprot.2 | P07340 |
| Cellular Localization | Cell membrane; Single-pass type II membrane protein . Apical cell membrane; Single-pass type II membrane protein . Cell membrane, sarcolemma . Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. . |
| Tissue Expression | Found in most tissues. |
| Signaling_pathway | Organismal Systems >> Endocrine system >> Insulin secretion;Organismal Systems >> Endocrine system >> Thyroid hormone signaling pathway;Organismal Systems >> Endocrine system >> Aldosterone synthesis and secretion;Organismal Systems >> Circulatory system >> Cardiac muscle contraction;Organismal Systems >> Circulatory system >> Adrenergic signaling in cardiomyocytes;Environmental Information Processing >> Signal transduction >> cAMP signaling pathway;Environmental Information Processing >> Signal transduction >> cGMP-PKG signaling pathway |
| Research Areas | |
| Function | This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane . Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 .; Involved in cell adhesion and establishing epithelial cell polarity. |
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