Name: Aurora A Rabbit pAb
SKU: WP5943
Price: 268 USD
Availability: InStock

Aurora A Rabbit pAb

Ucallm_WP5943-50

Price range: $268.00 through $328.00

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50μl

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SKU: WP5943-100

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Product details

Background:

Aurora A(AURKA) Homo sapiens The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene.

Specifications

Size	50μL/100μL
Target	Aurora A
Reactivity	Human, Mouse, Rat
Applications	IHC, WB
MW(Calculated)
MW(Observed)	46kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	IHC1:50-200; WB 1:1000-2000 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from human Aurora A AA range: 65-115
Specificity	This antibody detects endogenous levels of Aurora A at Human, Mouse,Rat
Gene Name	AURKA AIK AIRK1 ARK1 AURA AYK1 BTAK IAK1 STK15 STK6
Protein Name	Aurora A
Other Name	Aurora kinase A; / Aurora 2; / Aurora/IPL1-related kinase 1; / ARK-1; / Aurora-related kinase 1; / hARK1; / Breast tumor-amplified kinase; / Serine/threonine-protein kinase 15; / Serine/threonine-protein kinase 6; / Serine/threonine-protein kinase aurora-A
Species	Human
Gene ID	6790
Uniprot	O14965,
Species.1	Mouse
Gene ID.1	20878
Uniprot.1	P97477,
Species.2	Rat
Gene ID.2
Uniprot.2	P59241
Cellular Localization	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .
Tissue Expression	Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Signaling_pathway
Research Areas	>>Oocyte meiosis; / >>Progesterone-mediated oocyte maturation
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Aurora A Rabbit pAb

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Aurora A Rabbit pAb

Product details

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