SKU: WM0612 Categories: ,

Aurora Kinase A mouse mAb

Price range: $499.00 through $699.00

SKU: WM0612-50
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Product details

Background:
The protein encoded by this gene is a cell cycle-regulated kinase that appears to be involved in microtubule formation and/or stabilization at the spindle pole during chromosome segregation. The encoded protein is found at the centrosome in interphase cells and at the spindle poles in mitosis. This gene may play a role in tumor development and progression. A processed pseudogene of this gene has been found on chromosome 1, and an unprocessed pseudogene has been found on chromosome 10. Multiple transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

Specifications

Specification50μL;100μL
TargetAurora A
ReactivityHuman, Monkey
ApplicationsWB, IF
MW(Calculated)
MW(Observed)46kD
Host SpeciesMouse
Isotype
Conjugate
ModificationUnmodified
Recommended Dilution RatioWB 1:500;ICC 1:50;IF 1:50-200
CompositionLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source
Purification ProcessThe antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
Puity
Storage Condition-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
ClonalityMonoclonal
Clone Number
ImmunogenPurified recombinant human Aurora Kinase A protein fragments expressed in E.coli.
Sequence
SpecificityThis antibody detects endogenous levels of Aurora Kinase A and does not cross-react with related proteins.
Gene Nameaurka
Protein Name
AliasAIK;ARK-1;ARK1;AURA;AURKA;Aurora 2;Aurora A;Aurora Family Kinase 1;aurora kinase A;Aurora Related Kinase 1;Aurora-related kinase 1;Aurora/IPL1 Like Kinase;Aurora/IPL1 Related Kinase 1;Aurora/IPL1-related kinase 1;AURORA2;AYK1;BRAK;Breast Tumor Amplified Kinase;Breast tumor-amplified kinase;BTAK;hARK1;IAK;IPL1 Aurora Related Kinase 1;IPL1 Related Kinase;MGC34538;OTTHUMP00000031340;OTTHUMP00000031341;OTTHUMP00000031342;OTTHUMP00000031343;OTTHUMP00000031344;OTTHUMP00000031345;OTTHUMP00000166071;OTTHUMP00000166072;PPP1R47;Protein phosphatase 1, regulatory subunit 47;Serine/threonine kinase 15;Serine/threonine kinase 6;Serine/threonine kinase;Serine/threonine-protein kinase 15;Serine/threonine-protein kinase 6;Serine/threonine-protein kinase aurora-A;STK15;STK6;STK6_HUMAN;STK7.
Organism-1Human
Gene ID-16790
SwissProt-1O14965
Organism-2Mouse
Gene ID-2
SwissProt-2P97477
Organism-3
Gene ID-3
SwissProt-3
Organism-4
Gene ID-4
SwissProt-4
Cellular LocalizationCytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle pole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cell projection, neuron projection . Detected at the neurite hillock in developing neurons (By similarity). Localizes at the centrosome in mitotic cells from early prophase until telophase, but also localizes to the spindle pole MTs from prophase to anaphase (PubMed:9606188, PubMed:17229885, PubMed:21225229). Colocalized with SIRT2 at centrosome (PubMed:22014574). Moves to the midbody during both telophase and cytokinesis (PubMed:17726514). Associates with both the pericentriolar material (PCM) and centrioles (PubMed:22014574). The localization to the spindle poles is regulated by AAAS (PubMed:26246606). .
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