B-Myb (Phospho Thr494/497) Rabbit pAb
Ucallm_WP10807-50
Price range: $288.00 through $368.00
Product details
Background:
MYB proto-oncogene like 2(MYBL2) Homo sapiens The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013],
Specifications
| Size | 50μL/100μL |
| Target | B-Myb Phospho Thr494 |
| Reactivity | Human, Mouse |
| Applications | IHC, WB |
| MW(Calculated) | |
| MW(Observed) | 80kD |
| Host Species | Rabbit |
| Isotype | |
| Conjugate/Modification | phosphate |
| Recommended Dilution Ratio | WB 1:500-2000; IHC 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004) |
| Formulation | Liquid in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | Synthesized peptide derived from human B-Myb (Phospho Thr494/497) |
| Specificity | This antibody detects endogenous B-Myb when phosphorylated at thr494(human),thr497(mosue) |
| Gene Name | MYBL2 BMYB |
| Protein Name | Myb-related protein B (B-Myb) (Myb-like protein 2) |
| Other Name | Myb-related protein B; / B-Myb; / Myb-like protein 2 |
| Species | Human |
| Gene ID | 4605 |
| Uniprot | P10244, |
| Species.1 | Mouse |
| Gene ID.1 | 17865 |
| Uniprot.1 | P48972 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | Nucleus. |
| Tissue Expression | |
| Signaling_pathway | Cellular Processes >> Cell growth and death >> Cellular senescence |
| Research Areas | >>Cellular senescence |
| Function | Function:Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.,PTM:Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.,similarity:Contains 3 HTH myb-type DNA-binding domains.,subunit:Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22., |
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