Name: BCAS3 Polyclonal Antibody
SKU: WP11258
Price: 268 USD
Availability: InStock

BCAS3 Polyclonal Antibody

Ucallm_WP11258-50

Price range: $268.00 through $328.00

Size

100μl

50μl

Clear

SKU: WP11258-100

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Product details

Background:

developmental stage:Fetal., disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t(17;20)(q23;q13) with BCAS4., similarity:Belongs to the WD repeat BCAS3 family., similarity:Contains 3 WD repeats., tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.,

Specifications

Size	50μL/100μL
Target	BCAS3
Reactivity	Human, Mouse
Applications	WB, ELISA
MW(Calculated)
MW(Observed)	100kD
Host Species	Rabbit
Isotype	IgG
Conjugate/Modification	Unmodified
Recommended Dilution Ratio	WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications.
Formulation	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Storage	-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration	1 mg/ml
Clonality	Polyclonal
Clone Number
Immunogen	Synthesized peptide derived from BCAS3 . at AA range: 660-740
Specificity	BCAS3 Polyclonal Antibody detects endogenous levels of BCAS3 protein.
Gene Name	BCAS3
Protein Name	Breast carcinoma-amplified sequence 3
Other Name	BCAS3; / Breast carcinoma-amplified sequence 3; / GAOB1
Species	Human
Gene ID	54828
Uniprot	Q9H6U6,
Species.1	Mouse
Gene ID.1	192197
Uniprot.1	Q8CCN5
Species.2
Gene ID.2
Uniprot.2
Cellular Localization	Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Preautophagosomal structure . Localizes in the cytoplasm in stationary cells. Translocates from the cytoplasm to the leading edge in motile cells. Colocalizes with microtubules and intermediate filaments in both stationary and motile cells (By similarity). Associates with chromatin. Recruited to estrogen receptor-induced promoters in a PELP1-dependent manner. The BCAS3:PHAF1 complex is recruited to the preautophagosomal structures adjacent to the damaged mitochondria upon mitophagy in a PRKN-PINK1 dependent manner (PubMed:33499712). .
Tissue Expression	Expressed in stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leukocyte and mammary epithelial cells. Expressed in undifferentiated ES cells. Expressed in blood islands and nascent blood vessels derived from differentiated ES cells into embryoid bodies (BD). Expressed in endothelial cells. Not detected in brain. Expressed in brain tumors (at protein level). Expressed in brain. Highly expressed in breast cancers and in glioma cell lines.
Signaling_pathway
Research Areas
Function	developmental stage:Fetal.,Disease:A chromosomal aberration involving BCAS3 may be a cause of breast cancer. Translocation t(17; 20)(q23; q13) with BCAS4.,similarity:Belongs to the WD repeat BCAS3 family.,similarity:Contains 3 WD repeats.,tissue specificity:Stomach, liver, lung, kidney, prostate, testis, thyroid gland, adrenal gland, brain, heart, skeletal muscle, colon, spleen, small intestine, placenta, blood leucocyte and mammary epithelial cells. Overexpressed in most breast cancer cell lines.,

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BCAS3 Polyclonal Antibody

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BCAS3 Polyclonal Antibody

Product details

Specifications

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