Bcl-7a Polyclonal Antibody
Ucallm_WP11265-50
Price range: $268.00 through $328.00
Product details
Background:
This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Specifications
| Size | 50μL/100μL |
| Target | Bcl-7a |
| Reactivity | Human, Mouse |
| Applications | WB, ELISA |
| MW(Calculated) | |
| MW(Observed) | 22kD |
| Host Species | Rabbit |
| Isotype | IgG |
| Conjugate/Modification | Unmodified |
| Recommended Dilution Ratio | WB 1:500-1:2000; ELISA 1:5000; Not yet tested in other applications. |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Storage | -15°C to -25°C/1 year(Do not lower than -25°C) |
| Concentration | 1 mg/ml |
| Clonality | Polyclonal |
| Clone Number | |
| Immunogen | The antiserum was produced against synthesized peptide derived from human BCL7A. AA range:21-70 |
| Specificity | Bcl-7a Polyclonal Antibody detects endogenous levels of Bcl-7a protein. |
| Gene Name | BCL7A |
| Protein Name | B-cell CLL/lymphoma 7 protein family member A |
| Other Name | BCL7A; / B-cell CLL/lymphoma 7 protein family member A |
| Species | Human |
| Gene ID | 605 |
| Uniprot | Q4VC05, |
| Species.1 | Mouse |
| Gene ID.1 | 77045 |
| Uniprot.1 | Q9CXE2 |
| Species.2 | |
| Gene ID.2 | |
| Uniprot.2 | |
| Cellular Localization | |
| Tissue Expression | Brain,Thalamus, |
| Signaling_pathway | Genetic Information Processing >> Chromosome >> ATP-dependent chromatin remodeling |
| Research Areas | |
| Function | Disease:Chromosomal aberrations involving BCL7A may be a cause of B-cell non-Hodgkin lymphoma. Three-way translocation t(8; 14; 12)(q24.1; q32.3; q24.1) with MYC and with immunoglobulin gene regions.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the BCL7 family., |
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