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Home/Reagents/Antibody/Primary antibody/Monoclonal Antibody/Mouse mAb/Beclin-1 mouse Monoclonal Antibody [5C2]
SKU: WM1198 Categories: ,

Beclin-1 mouse Monoclonal Antibody [5C2]

Ucallm_WM1198-50

Price range: $268.00 through $328.00

SKU: WM1198-50
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Product details

Background:
beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

Specifications

Size50μL/100μL
TargetBeclin 1
ReactivityHuman, Mouse, Rat, Bovine
ApplicationsWB, IHC, IF
MW(Calculated)
MW(Observed)60kD
Host SpeciesMouse
Isotype
Conjugate/ModificationUnmodified
Recommended Dilution RatioWB 1:1000-2000; IHC 1:100-200; IF 1:50-200 / Note: For IHC, we suggest antigen retrieval with TE buffer pH 9.0 (Cat#WT1004)
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
PurificationThe antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Storage-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration1 mg/ml
ClonalityMonoclonal
Clone Number5C2
ImmunogenSynthetic Peptide of Beclin-1 at AA range of 110-190
SpecificityBeclin-1 protein detects endogenous levels of BECN1
Gene NameBECN1
Protein NameBECN1
Other NameBECN1
SpeciesHuman
Gene ID8678
UniprotQ14457,
Species.1Mouse
Gene ID.1
Uniprot.1O88597,
Species.2Rat
Gene ID.2
Uniprot.2Q91XJ1
Cellular LocalizationCytoplasm . Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein . Endosome membrane; Peripheral membrane protein . Endoplasmic reticulum membrane; Peripheral membrane protein . Mitochondrion membrane; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
Tissue ExpressionUbiquitous.
Signaling_pathwayCellular Processes >> Transport and catabolism >> Autophagy - animal;Cellular Processes >> Transport and catabolism >> Mitophagy - animal;Cellular Processes >> Cell growth and death >> Apoptosis - multiple species;Human Diseases >> Neurodegenerative disease >> Alzheimer disease;Human Diseases >> Neurodegenerative disease >> Amyotrophic lateral sclerosis;Human Diseases >> Neurodegenerative disease >> Huntington disease;Human Diseases >> Neurodegenerative disease >> Spinocerebellar ataxia;Human Diseases >> Neurodegenerative disease >> Pathways of neurodegeneration - multiple diseases;Environmental Information Processing >> Signal transduction >> Apelin signaling pathway
Research Areas>>Autophagy - other; / >>Mitophagy - animal; / >>Autophagy - animal; / >>Apoptosis - multiple species; / >>Apelin signaling pathway; / >>Alzheimer disease; / >>Amyotrophic lateral sclerosis; / >>Huntington disease; / >>Spinocerebellar ataxia; / >>Pathways of neurodegeneration - multiple diseases; / >>Shigellosis; / >>Kaposi sarcoma-associated herpesvirus infection
FunctionFunction:Plays a central role in autophagy (By similarity). May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.,similarity:Belongs to the beclin family.,subcellular location:Expressed in dendrites and cell bodies of cerebellar Purkinje cells.,subunit:Interacts with GOPC and GRID2. Interacts with AMBRA1. Probably forms a complex with AMBRA1 and PIK3C3 (By similarity). Interacts with BCL2 and BCL2L1.,tissue specificity:Ubiquitous.,
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